Ester is a chemical compound derived from an oxoacid (organic or inorganic) in which at least one –OH hydroxyl group is replaced by an –O– alkyl (alkoxy) group, 87-13-8, formula is C10H16O5, Name is Diethyl 2-(ethoxymethylene)malonate. as in the substitution reaction of a carboxylic acid and an alcohol. Formula: C10H16O5.
Lim, Andrew S. T.;Vincent, Isabel M.;Barrett, Michael P.;Gilbert, Ian H. research published 《 Small Polar Hits against S. aureus: Screening, Initial Hit Optimization, and Metabolomic Studies》, the research content is summarized as follows. The global prevalence of antibacterial resistance requires new antibacterial drugs with novel chem. scaffolds and modes of action. It is also vital to design compounds with optimal physicochem. properties to permeate the bacterial cell envelope. We described an approach of combining and integrating whole cell screening and metabolomics into early antibacterial drug discovery using a library of small polar compounds Whole cell screening of a diverse library of small polar compounds against Staphylococcus aureus gave compound I. Hit expansion was carried out to determine structure-activity relationships. A selection of compounds from this series, together with other screened active compounds, was subjected to an initial metabolomics study to provide a metabolic fingerprint of the mode of action. I and its analogs have a different mode of action from some of the known antibacterial compounds tested. This early study highlighted the potential of whole cell screening using a and metabolomics in early antibacterial drug discovery, and future works will include improving potency and performing orthogonal studies to confirm the modes of action.
87-13-8, Diethyl ethoxymethylenemalonate is a useful research compound. Its molecular formula is C10H16O5 and its molecular weight is 216.23 g/mol. The purity is usually 95%.
Diethyl ethoxymethylidenemalonate is a matrix effect reagent used in analytical chemistry. It is often used as a substrate for the cycloaddition process, which produces malondialdehyde and hydrochloric acid. The UV-absorption of the malondialdehyde can be measured to determine the concentration of the sample. Diethyl ethoxymethylidenemalonate is also used as a dna template in binding constants, where it binds with amines to form complexes that are then analyzed by light emission. It has been shown to have an inhibitory effect on gyrase and trifluoroacetic acid, both enzymes involved in DNA replication., Formula: C10H16O5
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics