Ester is a chemical compound derived from an oxoacid (organic or inorganic) in which at least one –OH hydroxyl group is replaced by an –O– alkyl (alkoxy) group, 87-13-8, formula is C10H16O5, Name is Diethyl 2-(ethoxymethylene)malonate. as in the substitution reaction of a carboxylic acid and an alcohol. Recommanded Product: Diethyl 2-(ethoxymethylene)malonate.
Khan, Nawaz Mohammed;Kumar, Pawan;Hemanth, Sudheer Kumar K.;Bharath, Rathna Kumar P. research published 《 Synthesis, molecular bioinformatics modelling, and antimicrobial evaluation of some novel oxadiazole fluoroquinolone derivatives》, the research content is summarized as follows. A series of oxadiazole fluoroquinolone derivatives I [Ar = Ph, 4-aminophenyl, 2-hydroxy-4-aminophenyl; R1 = Et, c-Pr; R2 = imidazol-1-yl, piperazin-1-yl] were synthesized with added derivatives such as Ph, aminophenyl, amino hydroxyphenyl along with cyclopropyl, Et, piperazine and imidazole. All of the newly produced mols. I were characterized by IR, 1H-NMR, mass spectrometry and elemental anal. technique and screened for docking stimulation to find out binding modes of synthesized derivatives with 3FV5, 5IMW and 5ESE and evaluated for in-vitro antimicrobial activity. From this study, it was found that the compound I [Ar = 4-aminophenyl, R1 = c-Pr, R2 = imidazol-1-yl] showed good antibacterial activity against Gram-pos. (Staphylococcus aureus), compound I [Ar = 2-hydroxy-4-aminophenyl, R1 = c-Pr, R2 = imidazol-1-yl] showed good antibacterial activity against Gram-neg. (Escherichia coli), and compound I [Ar = 2-hydroxy-4-aminophenyl, R1 = c-Pr, R2 = piperazin-1-yl] showed good antifungal activity against fungi (Saccharomyces cerevisiae) in comparison with standard drugs (Ciprofloxacin and fluconazole). The zone of inhibition and min. inhibitory concentration studies was performed on synthesized compounds I. The analogs of oxadiazole flouroquinolone I are suggested to be potent inhibitors with sufficient scope for further exploration.
87-13-8, Diethyl ethoxymethylenemalonate is a useful research compound. Its molecular formula is C10H16O5 and its molecular weight is 216.23 g/mol. The purity is usually 95%.
Diethyl ethoxymethylidenemalonate is a matrix effect reagent used in analytical chemistry. It is often used as a substrate for the cycloaddition process, which produces malondialdehyde and hydrochloric acid. The UV-absorption of the malondialdehyde can be measured to determine the concentration of the sample. Diethyl ethoxymethylidenemalonate is also used as a dna template in binding constants, where it binds with amines to form complexes that are then analyzed by light emission. It has been shown to have an inhibitory effect on gyrase and trifluoroacetic acid, both enzymes involved in DNA replication., Recommanded Product: Diethyl 2-(ethoxymethylene)malonate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics