Glycerides are fatty acid esters of glycerol; they are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils. 87-13-8, formula is C10H16O5, Name is Diethyl 2-(ethoxymethylene)malonate. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. HPLC of Formula: 87-13-8.
Kalbfleisch, Jacob J.;Reed, Carson W.;Park, Charlotte;Spearing, Paul K.;Quitalig, Marc C.;Jenkins, Matthew T.;Rodriguez, Alice L.;Blobaum, Anna L.;Jeffrey Conn, P.;Niswender, Colleen M.;Lindsley, Craig W. research published 《 Synthesis and SAR of a series of mGlu7 NAMs based on an ethyl-8-methoxy-4-(4-phenylpiperazin-1-yl)quinoline carboxylate core》, the research content is summarized as follows. A high-throughput screening (HTS) campaign identified a fundamentally new mGlu7 NAM chemotype, based on an Et 8-methoxy-4-(4-phenylpiperazin-1-yl)quinolinecarboxylate core. The initial hit, VU0226390 (I), was a potent mGlu7 NAM (IC50 = 647 nM, 6% L-AP4 min) with selectivity vs. the other group III mGlu receptors (>30μM vs. mGlu4 and mGlu8). A multi-dimensional optimization effort surveyed all regions of this new chemotype, and found very steep SAR, reminiscent of allosteric modulators, and unexpected piperazine mimetics (whereas classical bioisosteres failed). While mGlu7 NAM potency could be improved (IC50s ∼ 350 nM), the necessity of the Et ester moiety and poor physiochem. and DMPK properties precluded optimization towards in vivo tool compounds or clin. candidates. Still, this hit-to-lead campaign afforded key medicinal chem. insights and new opportunities.
HPLC of Formula: 87-13-8, Diethyl ethoxymethylenemalonate is a useful research compound. Its molecular formula is C10H16O5 and its molecular weight is 216.23 g/mol. The purity is usually 95%.
Diethyl ethoxymethylidenemalonate is a matrix effect reagent used in analytical chemistry. It is often used as a substrate for the cycloaddition process, which produces malondialdehyde and hydrochloric acid. The UV-absorption of the malondialdehyde can be measured to determine the concentration of the sample. Diethyl ethoxymethylidenemalonate is also used as a dna template in binding constants, where it binds with amines to form complexes that are then analyzed by light emission. It has been shown to have an inhibitory effect on gyrase and trifluoroacetic acid, both enzymes involved in DNA replication., 87-13-8.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics