Wang, Dan; Zhao, Li; Hao, Zhiyan; Huang, Ying; Liao, Yang; Wang, Lingli; Zhang, Jinfeng; Cao, Shan; Liu, Lixiao published the artcile< High-throughput and untargeted metabolic profiling revealed the potential effect and mechanisms of paeoniflorin in young asthmatic rats>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is asthma metabolic profiling paeoniflorin; action mechanism 3; biomarker; metabolites; metabolomics; pathways.
Paeoniflorin (PF) is a multi-target monoterpenoid glycoside and possesses broad pharmacol. functions, e.g., anti-inflammation, anti-depression, antitumor, abirritation, neuroprotection, antioxidant, and enhancing cognitive and learning ability. PF has gained a large amount of attention for its effect on asthma disease as the growth rate of asthma has increased in recent years. However, its mechanism of action on asthma is still unclear. In this study, we have explored the action mechanism of PF on asthma disease. Furthermore, high-throughput untargeted metabolic profiling was performed through ultraperformance liquid chromatog./electrospray ionization quadruple time-of-flight high-definition mass spectrometry (QA) UPLC-Q/TOF-MS combined with pattern recognition approaches and pathway anal. A total of 20 potential biomarkers were discovered by UPLC/MS and urine metabolic profiling. The key pathways including the citrate cycle (the TCA cycle), pyrimidine metabolism, pentose phosphate pathway, tyrosine metabolism, and tryptophan metabolism were affected by PF. In conclusion, we have discovered metabolite biomarkers and revealed the therapeutic mechanism of PF based on liquid chromatog. coupled with mass spectrometry untargeted metabolomics. The untargeted metabolomics combined with UPLC-MS is a useful tool for exploring the therapeutic mechanism and targets of PF in the treatment of asthma. Metabolomics combined with UPLC-MS is an integrated method to explore the metabolic mechanism of PF in the treatment of asthma rats and to reveal the potential targets, providing theor. support for the study of the treatment of PF.
Frontiers in Pharmacology published new progress about Asthma. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics