Ourhzif, El-Mahdi; Paris, Arnaud; Abrunhosa-Thomas, Isabelle; Ketatni, El Mostafa; Chalard, Pierre; Khouili, Mostafa; Daniellou, Richard; Troin, Yves; Akssira, Mohamed published the artcile< Design, synthesis, and evaluation of cytotoxic activities of arylnaphthalene lignans and aza-analogs>, Quality Control of 112-63-0, the main research area is lung cancer glioma melanoma justicidin C cytotoxicity antitumor; arylnaphthalene lactones; aza-arylnaphthalene lignans; cytotoxic activity; justicidin C; methoxy-vitedoamine A; retrojusticidin B; substituted naphthols.
A concise and versatile synthetic strategy for the total synthesis of arylnaphthalene lignans and aza-analogs was developed. The main objective was to develop synthetic tactics for the creation of the lactone and lactam unit that would give access to an array of synthetic, natural, and/or bioactive compounds through rather simple chem. manipulation. The flexibility and potentiality of these new processes were further illustrated by the total synthesis of retrojusticidin B (13b), justicidin C (14b), and methoxy-vitedoamine A (22a). In this study, a series of novel aryl-naphthalene lignans and aza-analogs were synthesized, and the cytotoxic activities of all compounds on cancer cell growth were evaluated. The target compounds were structurally characterized by 1H NMR (NMR), 13C NMR, IR, high-resolution mass spectrometry, and X-ray crystallog. The IC50 values of these compounds on five tumor cell lines (A549, HS683, MCF-7, SK-MEL-28, and B16-F1) were obtained by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) colorimetric assay. Five of the compounds exhibited excellent activity compared to 5-fluorouracil and etoposide against the five cell lines tested, with IC50 values ranging from 1 to 10娓璏.
Archiv der Pharmazie (Weinheim, Germany) published new progress about Antitumor agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics