Lukin, Kirill; Kishore, Vimal; Gordon, Thomas published the artcile< Development of a Scalable Synthesis of Oxadiazole Based S1P1 Receptor Agonists>, Electric Literature of 112-63-0, the main research area is scalable oxadiazole synthesis S1P1 receptor agonist; byproduct triphenylphosphine oxide removal magnesium complex formation; oxadiazole improved synthesis cyclization acylamidoxime DBU.
A robust and scalable synthesis was developed for the preparation of oxadiazole based S1P1 inhibitors I and II. A new method for the separation of triphenylphosphine oxide from reaction products and an improved method for the synthesis of oxadiazoles in the presence of DBU were incorporated into the process to achieve its scalability.
Organic Process Research & Development published new progress about Sphingosine-1-phosphate receptor 1 Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics