Kostenko, Alexey A.; Kucherenko, Alexander S.; Komogortsev, Andrey N.; Lichitsky, Boris V.; Zlotin, Sergei G. published the artcile< Asymmetric Michael addition between kojic acid derivatives and unsaturated ketoesters promoted by C2-symmetric organocatalysts>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is pyranopyran preparation enantioselective; pyranone unsaturated ketoester Michael addition hemiketalization; bifunctional tertiary amine squaramide organocatalyst preparation.
An efficient sterically hindered C2-sym. bifunctional tertiary amine-squaramide organocatalyst for the asym. Michael addition/hemiketalization domino reaction of kojic acid derivatives with ç?ç»?unsaturated æµ?ketoesters has been designed. Pharmacol.-relevant functionalized 2,3,4,8-tetrahydropyrano[3,2-b]pyran derivatives I (R1 = H, MeO, Cl, etc.; R2 = Ph, 1-furyl, 4-NCC6H4) were produced over the catalyst in as low as 1 mol% with up to 99% yield and 99% ee. The procedure is at least 30-fold scalable and the catalyst is readily reusable in the catalytic reaction via acid-base extraction Acylation of the products with (S)- or rac-ibuprofen and with undec-10-enoic acid afforded the corresponding chiral esters containing two privileged pharmacophoric motifs.
Organic & Biomolecular Chemistry published new progress about Bifunctional catalysts, organocatalysts. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics