El Gizawy, Heba A.; El-Haddad, Alaadin E.; Saadeldeen, Amr M.; Boshra, Sylvia A. published the artcile< Tentatively Identified (UPLC/T-TOF-MS/MS) Compounds in the Extract of Saussurea costus Roots Exhibit In Vivo Hepatoprotection via Modulation of HNF-1浼? Sirtuin-1, C/ebp浼? miRNA-34a and miRNA-223>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is Saussurea root rhoifolin HNF1A SIRT1 IL6 microRNA hepatotoxicity hepatoprotectant; Asteraceae; C/ebp浼? HNF-1浼? Saussurea lappa; Sirtuin-1; hepatoprotective; miRNA; phenolics.
Saussurea costus is a plant traditionally used for the treatment of several ailments. Our study accomplished the UPLC/T-TOF-MS/MS anal. of a methanol extract of Saussurea costus roots (MESC), in addition to lipoidal matter determination and assessment of its in vivo hepatoprotective activity. In this study, we were able to identify the major metabolites in MESC rather than the previously known isolated compounds, improving our knowledge of its chem. constituents. The flavones apigenin, acacetin, baicalein, luteolin, and diosmetin, and the flavonol aglycons quercetin, kaempferol, isorhamnetin, gossypetin, and myricetin and/or their glycosides and glucuronic derivatives were the major identified compounds The hepatoprotective activity of MESC was evaluated by measuring catalase activity using UV spectrophotometry, inflammatory cytokines and apoptotic markers using ELISA techniques, and genetic markers using PCR. Paracetamol toxicity caused a significant increase in plasma caspase 2, cytokeratin 18 (CK18), liver tumor necrosis factor-浼?(TNF-浼?, interleukin 6 (IL-6), miRNA-34a, and miRNA-223, as well as a significant decrease in liver catalase (CAT) activity and in the levels of liver nuclear factor 1浼?(HNF-1浼?, sirtuin-1, and C/ebp浼? Oral pretreatment with MESC (200 mg/kg) showed a significant decrease in caspase 2, CK18, TNF-浼? IL-6 and a significant increase in liver CAT activity. MESC decreased the levels of liver miRNA-34a and miRNA-223 and induced HNF-1浼? sirtuin-1, and C/ebp浼?gene expression. The histol. examination showed a significant normalization in rats pretreated with MESC. Our findings showed that Saussurea costus may exert a potent hepatoprotective activity through the modulation of the expression of cellular cytokines, miRNA-34a, and miRNA-223.
Molecules published new progress about Apoptosis. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.
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