Dolensky, Bohumil; Takeuchi, Yoshio; Cohen, Louis A.; Kirk, Kenneth L. published the artcile< Synthesis of 4,5-difluoroimidazole>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is imidazole difluoro preparation; photochem Schiemann reaction aminoimidazole fluorination.
5-Fluoroimidazole-4-carboxylic acid Et ester 3 was converted to the corresponding hydrazide 4 in 81% yield. Oxidation of the hydrazide to the carbonyl azide 5 (88%) and Curtius rearrangement in t-Bu alc. produced 94% 4-t-butyloxycarbonylamino-5-fluoroimidazole 6. Dissolution of the t-Bu carbamate in 50% HBF4, in situ diazotization of the resulting amine, and irradiation produced the target compound 1 in 36% yield from 6 by the photochem. Schiemann reaction.
Journal of Fluorine Chemistry published new progress about Curtius reaction. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics