De Vrieze, Jana; Louage, Benoit; Deswarte, Kim; Zhong, Zifu; De Coen, Ruben; Van Herck, Simon; Nuhn, Lutz; Kaas Frich, Camilla; Zelikin, Alexander N.; Lienenklaus, Stefan; Sanders, Niek N.; Lambrecht, Bart N.; David, Sunil A.; De Geest, Bruno G. published the artcile< Potent Lymphatic Translocation and Spatial Control Over Innate Immune Activation by Polymer-Lipid Amphiphile Conjugates of Small-Molecule TLR7/8 Agonists>, COA of Formula: C9H3F5O2, the main research area is spatial control small mol TLR7 TLR8 agonist amphiphile conjugate; immunomodulation; innate immunity; lipid amphiphiles; lymph nodes; polymers.
Uncontrolled systemic inflammatory immune triggering has hampered the clin. translation of several classes of small-mol. immunomodulators, such as imidazoquinoline TLR7/8 agonists for vaccine design and cancer immunotherapy. By taking advantage of the inherent serum-protein-binding property of lipid motifs and their tendency to accumulate in lymphoid tissue, we designed amphiphilic lipid-polymer conjugates that suppress systemic inflammation but provoke potent lymph-node immune activation. This work provides a rational basis for the design of lipid-polymer amphiphiles for optimized lymphoid targeting.
Angewandte Chemie, International Edition published new progress about Amphiphiles. 71195-85-2 belongs to class esters-buliding-blocks, and the molecular formula is C9H3F5O2, COA of Formula: C9H3F5O2.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics