Datir, Rawlings P.; Kwaghe, Vivian; Roy, Sunando; Frampton, Dan; Breuer, Judith; Ogbanufe, Obinna; Murtala-Ibrahim, Fati; Charurat, Man; Dakum, Patrick; Sabin, Caroline A.; Ndembi, Nicaise; Gupta, Ravindra K. published the artcile< Deep sequencing of HIV-1 reveals extensive subtype variation and drug resistance after failure of first-line antiretroviral regimens in Nigeria>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is DNA sequencing HIV1 drug resistance antiretroviral population.
Deep sequencing could improve understanding of HIV treatment failure and viral population dynamics. However, this tool is often inaccessible in low- and middle-income countries. To determine the genetic patterns of resistance emerging in West African HIV-1 subtypes during first-line virol. failure, and the implications for future antiretroviral options. Patients and methods: Participants were selected from a Nigerian cohort of people living with HIV who had failed first-line ART and subsequently switched to second-line therapy. Whole HIV-1 genome sequences were generated from first-line virol. failure samples with Illumina MiSeq. Mutations detected at é?% frequency were analyzed and compared by subtype. HIV-1 sequences were obtained from 101 participants (65% female, median age 30 years, median 32.9 mo of nevirapine- or efavirenz-based ART). Thymidine analog mutations (TAMs) were detected in 61%, other core NRTI mutations in 92% and NNRTI mutations in 99%. Minority variants (<20% frequency) comprised 18% of all mutations. K65R was more prevalent in CRF02AG than G subtypes (33% vs. 7%; P = 0.002), and é? TAMs were more common in G than CRF02AG (52% vs. 24%; P = 0.004). Subtype G viruses also contained more RT cleavage site mutations. Cross-resistance to at least one of the newer NNRTIs, doravirine, etravirine or rilpivirine, was predicted in 81% of participants. Extensive drug resistance had accumulated in people with West African HIV-1 subtypes, prior to second-line ART. Deep sequencing significantly increased the detection of resistance-associated mutations. Caution should be used if considering newer-generation NNRTI agents in this setting. Journal of Antimicrobial Chemotherapy published new progress about Antiviral agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.
Referemce:
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