Bai, Hualei; Chen, Shize; Yuan, Tiezheng; Xu, Dongyuan; Cui, Songbiao; Li, Xiangdan published the artcile< Paeoniflorin ameliorates neuropathic pain-induced depression-like behaviors in mice by inhibiting hippocampal neuroinflammation activated via TLR4/NF-榄廈 pathway>, Reference of 112-63-0, the main research area is paeoniflorin TLR NFkB hippocampal neuroinflammation activation neuropathic pain depression; Depression; Hippocampus; Neuralgia; Paeoniflorin; TLR4/NF-榄廈 pathway.
Neuropathic pain (NP) that contributes to the comorbidity between pain and depression is a clin. dilemma. Neuroinflammatory responses are known to have potentially important roles in the initiation of NP and depressive mood. In this study, we aimed to investigate the effects of paeoniflorin (PF) on NP-induced depression-like behaviors by targeting the hippocampal neuroinflammation through the toll-like receptor 4 (TLR4)/nuclear factor-kappa B (NF-榄廈) signaling pathway. We used a murine model of NP caused by unilateral sciatic nerve cuffing (Cuff). PF was injected i.p. once a day for a total of 14 days. Pain and depression-like behavior changes were evaluated via behavioral tests. Pathol. changes in the hippocampus of mice were observed by H&E staining. The levels of proinflammatory cytokines in the hippocampus were detected using ELISA. Activated microglia were measured by immunohistochem. staining. The TLR4/NF-榄廈 signaling pathwayassocd. protein expression in the hippocampus was detected by western blotting. We found that the PF could significantly alleviate Cuff-induced hyperalgesia and depressive behaviors, lessen the pathol. damage to the hippocampal cell, reduce proinflammatory cytokines levels, and inhibit microglial over-activation. Furthermore, PF downregulated the expression levels of TLR4/NF-榄廈 signaling pathwayrelated proteins in the hippocampus. These results indicate that PF is an effective drug for improving the comorbidity between NP and depression.
Korean Journal of Physiology & Pharmacology published new progress about Allodynia. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.
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