Thiyagarajan, Subramanian; Krishnakumar, Varadhan; Gunanathan, Chidambaram published an article in 2020, the title of the article was KOtBu-Catalyzed Michael Addition Reactions Under Mild and Solvent-Free Conditions.Quality Control of 3-Acetyldihydrofuran-2(3H)-one And the article contains the following content:
Herein, a mild and environmentally friendly strategy of readily available KOtBu-catalyzed Michael addition reactions was demonstrated. This simple inorganic base efficiently catalyzed the Michael addition of underexplored acrylonitriles, esters and amides with oxa-, aza-, and thia-heteroatom nucleophiles to afford Michael addition products. This catalytic process proceeded under solvent-free conditions and at room temperature Notably, this protocol offered an easy operational procedure, broad substrate scope with excellent selectivity, reaction scalability and excellent TON (>9900). Preliminary mechanistic studies revealed that the reaction followed an ionic mechanism. Formal synthesis of promazine was demonstrated using this catalytic protocol. The experimental process involved the reaction of 3-Acetyldihydrofuran-2(3H)-one(cas: 517-23-7).Quality Control of 3-Acetyldihydrofuran-2(3H)-one
The Article related to nitrile alkyl green preparation, acrylonitrile heteroatom nucleophile michael base catalyst, ester alkyl green preparation, acrylic ester heteroatom nucleophile michael base catalyst, amide alkyl green preparation, acrylamide heteroatom nucleophile michael base catalyst, michael addition, base catalysis, green synthesis, nitriles, sustainable chemistry and other aspects.Quality Control of 3-Acetyldihydrofuran-2(3H)-one
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