On May 28, 2009, Bennett, Nicholas J.; Mcinally, Thomas; Mochel, Tobias; Thom, Stephen; Tiden, Anna-Karin published a patent.Recommanded Product: 142327-44-4 The title of the patent was Preparation of pyrimidine derivatives for the treatment of various diseases. And the patent contained the following:
The title compounds I [R1 = alkyl, alkoxy, alkylthio;; R2 = II or III; R3 = H or alkyl; R4 = cycloalkyl, alkyl, alkenyl, alkynyl, etc.; X1 = O, S, NH or CH2; X2, X4 = a bond, O, S; R5, R51 = H or alkyl; R6 = (un)substituted alkyl or saturated heterocyclyl; j = 1-2; R7 = H, halo, OH, etc.; Z1 = alkylene or cycloalkylene; X3 = NR12, N(COR12), CONR12, etc.; Y1 = 0-2; Y1 = a bond, alkylene; A = monocyclic or bicyclic aryl or monocyclic or bicyclic heteroaryl containing 1-3 heteroatoms; R8 = (un)substituted alkyl; n = 0-2; R9 = halo, CN, OH, etc.; R12 = H, 3-8 membered (un)saturated heterocyclyl, alkyl, etc.], useful in the treatment of asthma, COPD, allergic rhinitis, allergic conjunctivitis, atopic dermatitis, cancer, hepatitis B, hepatitis C, HIV, HPV, bacterial infections and dermatosis, were prepared E,g. a multi-step synthesis of IV, starting from 2-amino-4-chloro-6-methylpyrimidine and pentylamine, was given. Exemplified compounds I were tested in human TLR7 assay. For example, IV showed pEC50 of 6.3. Pharmaceutical compositions comprising the compound I, alone or in combination with other therapeutic agent, were disclosed. The experimental process involved the reaction of Methyl 2-(3-formylphenyl)acetate(cas: 142327-44-4).Recommanded Product: 142327-44-4
The Article related to pyrimidine pyrimidinediamine preparation antiasthmatic antitumor antibacterial antiaids, copd allergic rhinitis conjunctivitis atopic dermatitis treatment pyrimidinediamine preparation, hepatitis b c hiv hpv dermatosis treatment pyrimidinediamine preparation, toll like receptor tlr 7 modulator pyrimidine pyrimidinediamine preparation and other aspects.Recommanded Product: 142327-44-4
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