On August 1, 2002, Arrhenius, Thomas; Chen, Mi; Cheng, Jie Fei; Huang, Yujin; Nadzan, Alex; Penuliar, Richard; Wallace, David; Zhang, Lin published a patent.HPLC of Formula: 53838-27-0 The title of the patent was Preparation of hydroxyhexafluoropropylazoles, -azines, and alkynes as malonyl-CoA decarboxylase inhibitors useful as metabolic modulators. And the patent contained the following:
Pharmaceutical compositions for inhibiting malonyl-CoA decarboxylase (MCD) comprising ZF2CCWX(AY) [W = (substituted) 5-membered nonaromatic heterocyclyl containing 1 double bond, 6-membered heterocyclyl containing 0-2 double bonds, alkynyl, 5-6 membered heteroaryl; A = O, S, NR3; X = H, CF2Z, CF3; XY = double bond; Z = F, Br, Cl, iodo, CF3], are claimed. Thus, 2-[2-(butylamino)thiazol-5-yl]-1,1,1,3,3,3-hexafluoropropan-2-ol (preparation given) was refluxed 4 h with EtNCO in benzene to give N-butyl-N’-ethyl-N-[5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]thiazol-2-yl]urea. Tested title compounds inhibited MCD with IC50 = 0.024-3.71 μM. The experimental process involved the reaction of (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate(cas: 53838-27-0).HPLC of Formula: 53838-27-0
The Article related to azole preparation malonyl coa decarboxylase inhibitor, thiazole hexafluorohydroxypropyl acylamino preparation malonyl coa decarboxylase inhibitor, fatty acid glucose metabolism disorder treatment azole, cardiovascular disease treatment azole preparation, angina pectoris treatment azine, obesity treatment alkyne, acidosis treatment azole, cancer treatment azole and other aspects.HPLC of Formula: 53838-27-0
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