Shah, Muddaser; Murad, Waheed; Ur Rehman, Najeeb; Mubin, Sidra; Al-Sabahi, Jamal Nasser; Ahmad, Manzoor; Zahoor, Muhammad; Ullah, Obaid; Waqas, Muhammad; Ullah, Saeed; Kamal, Zul; Almeer, Rafa; Bungau, Simona G.; Al-Harrasi, Ahmed published the artcile< GC-MS Analysis and Biomedical Therapy of Oil from n-Hexane Fraction of Scutellaria edelbergii Rech. f.: In Vitro, In Vivo, and In Silico Approach>, Synthetic Route of 112-63-0, the main research area is hexane oil scutellaria edelbergii biomedical therapy; GC-MS analysis; analgesic assay; anti-diabetics; anti-inflammatory; antibacterial activity; antioxidants.
The current study aimed to explore the crude oils obtained from the n-hexane fraction of Scutellaria edelbergii and further analyzed, for the first time, for their chem. composition, in vitro antibacterial, antifungal, antioxidant, antidiabetic, and in vivo anti-inflammatory, and analgesic activities. For the phytochem. composition, the oils proceeded to gas chromatog.-mass spectrometry (GC-MS) anal. and from the resultant chromatogram, 42 bioactive constituents were identified. Among them, the major components were linoleic acid Et ester (19.67%) followed by Et oleate (18.45%), linolenic acid Me ester (11.67%), and palmitic acid Et ester (11.01%). Tetrazolium 96-well plate MTT assay and agar-well diffusion methods were used to evaluate the isolated oil for its min. inhibitory concentrations (MIC), min. bactericidal concentration (MBC), half-maximal inhibitory concentrations (IC50), and zone of inhibitions that could determine the potential antimicrobial efficacy鈥瞫. Anti-glucosidase potential was visualized through mol. docking simulations where ten compounds of the oil were found to be the leading inhibitors of the selected enzyme based on interactions, binding energy, and binding affinity. The oil from the n-hexane fraction of S. edelbergii contained valuable bioactive constituents that can act as in vitro biol. and in vivo pharmacol. agents. However, further studies are needed to uncover individual responsible compounds of the observed biol. potentials which would be helpful in devising novel drugs.
Molecules published new progress about Anti-inflammatory agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics