Lv, Leiyang; Lu, Shenglin; Chen, Yuanjin; Li, Zhiping published the artcile< Diastereoselective building up polycyclic tetrahydrofurans via tandem annulation of 1,n-enynes with aliphatic acids>, Quality Control of 112-63-0, the main research area is quinolinyl polycyclic THF diastereoselective preparation crystal structure mol; aniline linked enyne aliphatic acid tandem annulation silver catalyst.
A silver-catalyzed tandem annulation of aniline-linked 1,7-enynes with aliphatic acids was reported. This synergistic tandem annulations allowed the straightforward and efficient building up various highly diastereoselective polycyclic tetrahydrofurans. Primary and secondary acids underwent decarboxylation/cascade radical addition/ä¼?C(sp3)-H cleavage/cycloalkylation/O-trapping to generate oxygenous [6.6.6.5] fused products I [R = H, Me, F; R1 = Ac, Ms, SO2Ph, Ts, Bs; R2 = CO2Me, CO2Et, CO2t-Bu; n = 0,1] and II [R3 = R4 = H, Et; R3R4 = (CH2)2, (CH2)3, (CH2)OCH2, etc.]. While tertiary acids underwent decarboxylation/cascade radcial addition/å°?C(sp3)-H cleavage/O-trapping to give oxygenous [6.6.6.6] fused products III [R1 = Me, Ms, SO2Ph, Ts, Bs; R2 = Me, CO2Me, CO2Et, CO2t-Bu; R3 = H, Me; X = CH2, C=O].
Organic Chemistry Frontiers published new progress about Aliphatic acids Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics