Lee, Hesol; Lee, Sullim; Baek, Ji Yun; Seo, Chang-Seob; Yun, Hwayoung; Kim, Su-Nam; Kang, Ki Sung; Choi, You-Kyung published the artcile< Estrogenic activity of ethyl gallate and its potential use in hormone replacement therapy>, Product Details of C19H34O2, the main research area is ethyl gallate estrogen receptor component hormone replacement therapy; Estrogen receptor; Ethyl gallate; Hormone replacement therapy.
We aimed to compare the estrogenic activities of compounds isolated from Moutan Cortex Radicis (MRC, Paeonia suffruticosa Andrews) and identify their potential use in hormone replacement therapy. We quantified seven marker components (gallic acid, oxypaeoniflorin, paeoniflorin, Et gallate, benzoic acid, benzoylpaeoniflorin, and paeonol) in MRC using a high-performance liquid chromatog. simultaneous anal. assay. To investigate the estrogenic activity of MRC and the seven marker components, an E-screen assay was conducted using the estrogen receptor (ER)-pos. MCF-7 human breast cancer cell line. Among them, Et gallate caused cell proliferation in a concentration-dependent manner at concentrations above 25渭M and was clearly suppressed by combination treatment with the ER antagonist ICI 182,780. Therefore, Et gallate may be a compound of MRC that can increase the estrogenic effect in ER-pos. MCF-7 cells.
Bioorganic & Medicinal Chemistry Letters published new progress about Cell proliferation. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.
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