Graf, Roderich’s team published research in Journal fuer Praktische Chemie (Leipzig) in 1932 | 112-63-0

Journal fuer Praktische Chemie (Leipzig) published new progress about History. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Graf, Roderich published the artcile< 2-Methyl-5-aminopyridine and its derivatives>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is .

Details are given of the preparation of aldehydocollidine (Ger. pat. 349,184) and its oxidation to 6-methylnicotinic acid (1). The HCl salt of I and SOCl2 do not react below the b. p. of the SOCl2; at the b. p. there results an intensely green-reddish brown dye; MeOH-HCl gives the Me ester of I, m. 32� the ester seps. on warming the aqueous solution as an oil; Et ester, b15 130� b. 222-4�(slight decomposition); amide, m. 194� hydrazide (II), m. 134-5�(benzal derivative, m. 184-5� o-chlorobenzal derivative, m. 183-4� vanillal derivative, m. 245-60�; II and KNO: in N HCl give the azide (III), m. 44-5� and sec-bis(6-metkylnicotinic acid) hydraside, m. 247-50� III and PhNH2 in Et2O give the anilide of I, m. 134-7� 2-methyl-5-aminopyridine and III give N-(6-methyl-3-pyridoyl)-6-methyl-3-aminopyridine, m. 275-7�(decomposition). Boiling III in absolute EtOH gives 2-methyl-5-carbethoxyaminopyridine, m. 132-3� while boiling H2O gives sym-bis(2-methyl-5-pyridoyl)urea, m. 285-8�(decomposition); heating the latter with concentrated HCl at 130�for 10 hrs. gives 2-methyl-5-aminopyridine (IV), m. 95-6� heating III in dilute AcOH gives only a poor yield of IV; the amide (40 g.) and NaOCl give 18 g. VI. The di-HCl salt of IV m. 215-8�(decomposition); Ac derivative, m. 122-3� Bz derivative, m. 110-1� IV, through the diazo solution, gives the 5-Cl derivative, b. 163� m. 19� oxidation gives 5-chloropyridine-2-carboxylic acid, crystals with 1 mol. H2O, m. 169-70� chloride, m. 94� Me ester, m. 85-7� Ph ester, m. 92� amide, m. 200-1� 2-Methyl-5-bromopyridine, m. 32� 5-bromopyridine-2-carboxylic acid, m. 175� 2-Methyl-5-iodopyridine, m. 48-9� HI salt, m. 235-8� 5-iodopyridine-2-carboxylic acid, m. 188-90� 2-Methyl-5-hydroxypyridine, m. 165-7�

Journal fuer Praktische Chemie (Leipzig) published new progress about History. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics