Zhang, Chun; Zhang, Chao; Tang, Jie; Ye, Shengqing; Ma, Mingliang; Wu, Jie published an article in 2021. The article was titled 《Synthesis of γ-Keto Sulfones through a Three-Component Reaction of Cyclopropanols, DABCO·(SO2)2 and Alkyl Halides》, and you may find the article in Advanced Synthesis & Catalysis.Recommanded Product: Methyl 4-fluorobenzoate The information in the text is summarized as follows:
A route to γ-keto sulfones RC(O)(CH2)2SO2R1 [R = 4-FC6H4, Bn, 2-naphthyl, etc.; R1 = Me, Bn, 4-BrC6H4CH2, etc.] through a metal-free reaction of cyclopropanols, DABCO·(SO2)2 and alkyl halides was described. This reaction occurs under mild conditions in the absence of any catalysts, additives, or oxidants. Various functional groups including as ester, amino, methoxy, bromo, trifluoromethyl, nitro and carbonyl were tolerated well in this transformation and the corresponding γ-keto sulfones were afforded in 35% to 95% yields. The proposed mechanism implies that this reaction proceeded through γ-keto sulfinate intermediate generated in situ, which further undergoes nucleophilic substitution with alkyl halides leading to γ-keto sulfones. In the experiment, the researchers used Methyl 4-fluorobenzoate(cas: 403-33-8Recommanded Product: Methyl 4-fluorobenzoate)
Methyl 4-fluorobenzoate(cas: 403-33-8) can be used in the synthesis of trisubstituted imidazole derivatives containing a 4-fluorophenyl group, a pyrimidine ring, and a CN- or CONH2-substituted benzyl moiety.Recommanded Product: Methyl 4-fluorobenzoate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics