Wu, Xiaofang; Zhou, Lei; Li, Fangshao; Xiao, Jing published an article in 2021. The article was titled 《PCl3-mediated transesterification and aminolysis of tert-butyl esters via acid chloride formation》, and you may find the article in Journal of Chemical Research.Product Details of 403-33-8 The information in the text is summarized as follows:
A PCl3-mediated conversion of tert-Bu esters into esters R1C(O)OR2 [R1 = Ph, 4-MeC6H4, 4-ClC6H4, etc.; R2 = Me, Et, i-Pr, etc.] and amides R1C(O)NR2R3 [R1 = Ph, n-Bu, CH2Bn, etc.; R2 = Ph, n-Bu, Bn, etc.; R3 = H, Me, Ph] in one-pot under air was developed. This novel protocol highlighted by the synthesis of skeletons of bioactive mols. and gram-scale reactions. Mechanistic studies revealed that this transformation involved the formation of an acid chloride in situ, which was followed by reactions with alcs. or amines to afford the desired products. In the part of experimental materials, we found many familiar compounds, such as Methyl 4-fluorobenzoate(cas: 403-33-8Product Details of 403-33-8)
Methyl 4-fluorobenzoate(cas: 403-33-8) can be used in the synthesis of trisubstituted imidazole derivatives containing a 4-fluorophenyl group, a pyrimidine ring, and a CN- or CONH2-substituted benzyl moiety.Product Details of 403-33-8
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics