Thakur, Kratima; Khare, Naveen K. published the artcile< Copper mediated A3-coupling reaction for the preparation of enantioselective deoxy sugar based chiral propargylamine using bifunctional ligand L-proline>, Recommanded Product: (2R,3R,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate, the main research area is glycoside propargylamine proline copper catalyst coupling preparation aldehyde; copper catalyst coupling preparation enantioselective deoxy sugar propargylamine proline; A(3)-coupling reaction; C–H bond activation; Enantioselectivity; Propargylamines; l-proline.
An efficient three component coupling of aromatic aldehyde, deoxy sugar based alkyne (α-2-deoxy propargyl glycoside) and heterocyclic amine have been refluxed to synthesize stereoselective chiral propargylamine with good to excellent yield using only CuI catalyst along with bifunctional ligand L-proline. This method has proved to be applicable in wide range of substrates and found highly enantioselective with respect to earlier reported methods. In addition, L-proline was found as a chiral source which demonstrated that it could be developed as a highly enantioselective method for the construction of deoxy sugar based chiral propargylamine. The ligand L-proline was used for the first time in enantioselective A3-coupling reaction of α-2-deoxy propargyl glycosides involving substituted aromatic aldehyde and heterocyclic amines. Herein, we have synthesized 15 novel compounds based on A3-coupling reaction and structures of all the enantioselective compounds were characterized by TLC and NMR spectroscopy.
Carbohydrate Research published new progress about Aryl aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 4098-06-0 belongs to class esters-buliding-blocks, and the molecular formula is C12H16O7, Recommanded Product: (2R,3R,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics