Shalmani, Armin Azadkhah; Ghahremani, Mohammad Hossein; Jeivad, Fereshteh; Shadboorestan, Amir; Hassanzadeh, Gholamreza; Beh-Pajooh, Abbas; Ganbari-Erdi, Mikhriy; Kasirzadeh, Sara; Mojtahedzadeh, Mojtaba; Sabzevari, Omid published the artcile< Monomethyl fumarate alleviates sepsis-induced hepatic dysfunction by regulating TLR-4/NF-κB signalling pathway>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is sepsis hepatic dysfunction monomethyl fumarate TLR 4 NF kappaB; Hepatic impairment; Monomethyl fumarate; NF-κB; Sepsis; TLR-4.
Sepsis is a potentially fatal illness that can lead to impairment of multiple organs such as liver. The condition is deeply associated with oxidative stress and inflammation. The aim of current study was to evaluate protective effects of MMF in sepsis-induced hepatic dysfunction. Wistar rats were assigned to one of sham, CLP, CLP + dexamethasone (as pos. control of inflammation) and CLP + MMF groups. Levels of serum IL-1β, IL-6, IL-10, AST, ALT and γ-GT were quantified. Furthermore, Hepatic levels of GSH and MDA and mRNA expression of TNF and NFKBIA along with hepatic protein level of TLR-4 were assessed. Septic rats demonstrated risen levels of IL-1β, IL-6, IL-10, AST, ALT and γ-GT, while treatment with dexamethasone or MMF attenuated these levels. Moreover, enhancements in protein level of TLR-4 and mRNA levels of TNF and NFKBIA were observed in CLP rats. These elevations were mitigated in CLP-induced rats that were treated with either dexamethasone or MMF. Treatment with dexamethasone or MMF also shifted sepsis-induced disturbance in the levels of GSH and MDA towards sham levels. Hepato-protective effects of dexamethasone and MMF were further confirmed by histopathol. observations. Our findings imply that MMF alleviates sepsis-induced hepatic dysfunction by mitigating the inflammatory and oxidative state and this effect is at least partly mediated by the inhibition of TLR-4/NF-κB signalling pathway.
Life Sciences published new progress about Antioxidants. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.
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