Sgarbi, Gianluca; Hitrec, Timna; Amici, Roberto; Baracca, Alessandra; Di Cristoforo, Alessia; Liuzzi, Francesca; Luppi, Marco; Solaini, Giancarlo; Squarcio, Fabio; Zamboni, Giovanni; Cerri, Matteo published the artcile< Mitochondrial respiration in rats during hypothermia resulting from central drug administration>, Application In Synthesis of 112-63-0, the main research area is mitochondrial respiration hypothermia muscimol N6 cyclohexyladenosine; Adenosine; Hypothermia; Mitochondria; Raphe pallidus; Torpor.
The ability to induce a hypothermia resembling that of natural torpor would be greatly beneficial in medical and non-medical fields. At present, two procedures based on central nervous pharmacol. manipulation have been shown to be effective in bringing core body temperature well below 30 °C in the rat, a non-hibernator: the first, based on the inhibition of a key relay in the central thermoregulatory pathway, the other, based on the activation of central adenosine A1 receptors. Although the role of mitochondria in the activation and maintenance of torpor has been extensively studied, no data are available for centrally induced hypothermia in non-hibernators. Thus, in the present work the respiration rate of mitochondria in the liver and in the kidney of rats following the aforementioned hypothermia-inducing treatments was studied. Moreover, to have an internal control, the same parameters were assessed in a well-consolidated model, i.e., mice during fasting-induced torpor. Our results show that state 3 respiration rate, which significantly decreased in the liver of mice, was unchanged in rats. An increase of state 4 respiration rate was observed in both species, although it was not statistically significant in rats under central adenosine stimulation. Also, a significant decrease of the respiratory control ratio was detected in both species. Finally, no effects were detected in kidney mitochondria in both species. Overall, in these hypothermic conditions liver mitochondria of rats remained active and apparently ready to be re-activated to produce energy and warm up the cells. These findings can be interpreted as encouraging in view of the finalization of a translational approach to humans.
Journal of Comparative Physiology, B: Biochemical, Systems, and Environmental Physiology published new progress about Brain (temperature). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.
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