Scheffel, Thamiris Becker; Rockenbach, Liliana; Cruz, Fernanda Fernandes; Kist, Luiza Wilges; Bogo, Mauricio Reis; Scholl, Juliete Nathali; Figueiro, Fabricio; Lenz, Guido; Morrone, Fernanda Bueno published the artcile< Inhibition of ATP hydrolysis as a key regulator of temozolomide resistance and migratory phenotype of glioblastoma cells>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is ATP hydrolysis temozolomide cell migration phenotype glioblastoma; ATP; CD39; Ectoenzyme; Glioblastoma; Migration; Temozolomide.
Glioblastoma (GBM) is the most lethal among malignant gliomas. The tumor invasiveness and therapy-resistance are important clin. hallmarks. Growing evidence emphasizes the purinergic signaling contributing to tumor growth. Here we exposed a potential role of extracellular ATPase activity as a key regulator of temozolomide cytotoxicity and the migration process in GBM cells. The inhibition of ATP hydrolysis was able to improve the impact of temozolomide, causing arrest mainly in S and G2 phases of the cell cycle, leading M059J and U251 cells to apoptosis. In addition to eradicating GBM cells, ATP hydrolysis exhibited a potential to modulate the invasive phenotype and the expression of proteins involved in cell migration and epithelial-to-mesenchymal-like transition in a 3D culture model. Finally, we suggest the ATPase activity as a key target to decline temozolomide resistance and the migratory phenotype in GBM cells.
Biochemical and Biophysical Research Communications published new progress about Apoptosis. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.
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