Sarmah, Bikash Kumar; Konwar, Monuranjan; Bhattacharyya, Dipanjan; Adhikari, Priyanka; Das, Animesh published the artcile< Regioselective Cyanation of Six-Membered N-Heteroaromatic Compounds Under Metal-, Activator-, Base- and Solvent-Free Conditions>, Formula: C19H34O2, the main research area is heteroaromatic nitrogen oxide preparation trimethylsilyl cyanide cyanation microwave irradiation; cyano azaarene preparation regioselective.
A regioselective cyanation of heteroaromatic N-oxides with trimethylsilyl cyanide was developed to obtain 2-substituted N-heteroaromatic nitriles without the requirement of any external activator-, metal-, base- and solvent. The present protocol was a straightforward, one-pot heteroaromatic C-H cyanation process and proceeded smoothly in conventional heating but also under microwave irradiation with shorter reaction times. This approach now allowed access to a broad class of quinoline N-oxides and other heteroarene N-oxides with high to good yields and can also be scaled up to obtain gram quantities. Further application of this process was observed and utilized in late-stage cyanation of the anti-malarial drug quinine as well as transformation of the 2-cyanoazines to a series of biol. important mols. Based on the exptl. observations, a plausible mechanism was also proposed highlighting the dual role of trimethylsilyl cyanide as a nitrile source and as an activating agent.
Advanced Synthesis & Catalysis published new progress about Aromatic nitriles Role: PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics