O’Toole, Sarah E.; Rose, Christopher A.; Gundala, Sivaji; Zeitler, Kirsten; Connon, Stephen J. published the artcile< Highly chemoselective direct crossed aliphatic-aromatic acyloin condensations with triazolium-derived carbene catalysts>, Synthetic Route of 112-63-0, the main research area is hydroxylketone derivative preparation; aliphatic aldehyde aromatic aldehyde acyloin condensation triazolium precatalyst.
It has been shown for the first time that triazolium precatalysts promote (in the presence of base) highly chemoselective crossed acyloin condensation reactions between aliphatic and ortho-substituted aromatic aldehydes. An o-bromine atom can serve as a temporary directing group to ensure high chemoselectivity (regardless of the nature of the other substituents on the aromatic ring) which then can be conveniently removed. The process is of broad scope and is operationally simple as it does not require the preactivation of any of the coupling partners to ensure selectivity. Preliminary data indicate that highly enantioselective variants of the reaction are feasible using chiral precatalysts.
Journal of Organic Chemistry published new progress about Acyloin condensation. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics