Ni, Hangcheng; Li, Chaoming; Shi, Xingzi; Hu, Xianyue; Mao, Hui published an article in 2022. The article was titled 《Visible-Light-Promoted Fe(III)-Catalyzed N-H Alkylation of Amides and N-Heterocycles》, and you may find the article in Journal of Organic Chemistry.Application of 4248-19-5 The information in the text is summarized as follows:
A wide variety of amides RNH2 (R = benzoyl, 2-phenylacetyl, N-benzoylcarbamoyl, etc.) and nitrogen-containing heterocycles e.g., 1,3-dimethyl-3,9-dihydro-1H-purine-2,6-dione was tolerated in this protocol to give N-alkylated products I (R1 = H, Me; X = O, S) and e.g., II resp. The applicability of this protocol was further demonstrated by late-stage alkylation of N-H-containing pharmaceuticals. Moreover, N-H-alkylated α-amino tetrahydrofurans could be transformed into versatile ring-opened amino alcs. RNH(CH2)4OH under reducing conditions. A mechanistic study revealed that hydrogen atom transfer by a tert-butoxyl radical and a chlorine radical was responsible for the activation of C(sp3)-H precursors. The experimental process involved the reaction of tert-Butyl carbamate(cas: 4248-19-5Application of 4248-19-5)
tert-Butyl carbamate(cas: 4248-19-5) belongs to anime. Primary amines having a tertiary alkyl group (R3CNH2) are difficult to prepare with most methods but are made industrially by the Ritter reaction. In this method a tertiary alcohol reacts with hydrogen cyanide (HCN) in the presence of a concentrated strong acid; a formamide, RNH―CHO, is formed first, which then undergoes hydrolysis.Application of 4248-19-5
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