Miller, Max W.; Mylari, Banavara L.; Howes, Harold L. Jr.; Figdor, Sanford K.; Lynch, Martin J.; Lynch, John E.; Gupta, Shyam K.; Chappel, Larry R.; Koch, Richard C. published the artcile< Anticoccidial derivatives of 6-azauracil. 4. A 1000-fold enhancement of potency by phenyl sulfide and phenyl sulfone side chains>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is azauracil analog preparation anticoccidial.
Thirty-nine 6-azauracils I (R and R1 = H, Cl, Me, etc.; X = Me or substituted phenyl; n = 0-2) were synthesized and tested for anticoccidial activity. These compounds prevented a broad spectrum of coccidial infections in chickens at a min. inhibitory concentrations by weight in feed as low as 0.25 ppm, a 4000-fold increase in potency over 6-azauracil, and had shorter plasma half-lives than earlier potent analogs. Sulfides were more potent than sulfones, although they were oxidized rapidly to sulfones in vivo. I (R = R1 = Me; X = C6H4Cl-p; n = 0) [35319-70-1] controlled all the major species of poultry coccidia at low concentrations, but elicited toxicol. symptoms suggesting interference with nucleic acid synthesis.
Journal of Medicinal Chemistry published new progress about Coccidiosis. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics