McIsaac, W. M.; Williams, R. T. published the artcile< Detoxication. LXX. Metabolism of hydrazide and hydroxamic acids derived from salicylic acid>, Computed Properties of 112-63-0, the main research area is SALICYLAMIDES.
A study has been made of the fate of salicylic acid hydrazide (I) and its N-acetyl derivative and of salicylohydroxamic acid (II) and its 5-Br derivative in the rabbit. II and its 5-Br derivative have also been studied in man, rat, and mouse. I is metabolized mainly by conjugation with glucuronic acid (55% of dose) and partly by hydrolysis to salicylic acid, which is excreted mainly as salicyluric acid. N1-Acetyl-N2-salicylohydrazine is not deacetylated and is excreted mainly as its glucuronide (70% of the dose). These hydrazides do not form ethereal sulfates. Their glucuronides have been isolated. II is metabolized by direct conjugation with glucuronic acid and H2SO4 in the rabbit, and there is practically no conversion into salicylamide. The glucuronide was isolated. In man, mouse, and the rat, it forms considerable amounts of salicylamide which is excreted conjugated. 5-Bromosalicylohydroxamic acid is excreted by man, mouse, rabbit, and rat mainly as conjugates of 5-bromosalicyl-amide and to a lesser extent as the glucuronide of the acid. The glucuronides of the amide and acid were isolated from rabbit urine. The in vitro tuberculostatic activity of the amide is about 1/2 that of the acid, its precursor in vivo. The toxicity of aroyl hydrazides and hydroxamic acids in relation to their metabolism is discussed.
Biochemical Journal published new progress about Urine. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics