《Facile amidation of esters with aromatic amines promoted by lanthanide tris (amide) complexes》 was written by Li, Zhao; Guo, Chenjun; Chen, Jue; Yao, Yingming; Luo, Yunjie. Name: Methyl 4-fluorobenzoate And the article was included in Applied Organometallic Chemistry in 2020. The article conveys some information:
The development of catalysts capable of catalyzing amidation of esters with amines to construct amides under mild conditions is of great importance. Compared to aliphatic amines, the direct catalytic amidation of esters with less nucleophilic aromatic amines was rather difficult. Employing simple lanthanide tris (amide) complexes Ln[N (SiMe3)2]3(μ-Cl)Li (THF)3 as the catalysts, it was found a broad range of aromatic amines and esters were efficiently converted into various amides in good yields under mild conditions. A plausible mechanism for this transformation was exptl. supported as starting from an amide exchange reaction between the lanthanide tris (amide) complex and the substrate amine. The experimental part of the paper was very detailed, including the reaction process of Methyl 4-fluorobenzoate(cas: 403-33-8Name: Methyl 4-fluorobenzoate)
Methyl 4-fluorobenzoate(cas: 403-33-8) can be used in the synthesis of trisubstituted imidazole derivatives containing a 4-fluorophenyl group, a pyrimidine ring, and a CN- or CONH2-substituted benzyl moiety.Name: Methyl 4-fluorobenzoate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics