Li, Shoulei; Zhang, Enge; Feng, Junjun; Li, Xin published the artcile< An enantioselective conjugate addition reaction of 3-substituted benzothiophen-2-ones and 2-phthalimidoacrylates>, Synthetic Route of 112-63-0, the main research area is chiral benzothiophenone preparation; benzothiophenone phthalimidoacrylate enantioselective conjugate addition.
A highly enantioselective conjugate addition reaction of 3-substituted benzothiophen-2-ones to 2-phthalimidoacrylates has been developed using a bifunctional tertiary-amine thiourea catalyst. A number of chiral 3-substituted benzothiophen-2-one compounds I (R1 = Bn, i-Bu, (CH2)2COOMe, etc.; R2 = CH3, C2H5, Bn, etc.) were obtained with excellent yields (up to 99%) and very good stereoselectivities (up to >19 : 1 dr and up to 92% ee). The reaction was proved to be an efficient strategy for the synthesis of enantioenriched α-amino acid derivatives with 1,3-nonadjacent stereogenic centers.
Organic Chemistry Frontiers published new progress about Aromatic esters Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics