Li, Bin; Cheng, Xuan; Guan, Zhen-Yu; Li, Si-Yuan; Huo, Tao; Cheng, Guo; Fan, Yan-Hui; Zhou, Fang-Shuai; Deng, Qing-Hai published the artcile< Zinc-catalyzed asymmetric nitrooxylation of β-keto esters/amides with a benziodoxole-derived nitrooxy transfer reagent>, Related Products of 112-63-0, the main research area is nitrooxy keto ester preparation enantioselective; cyclic keto ester benziodoxole nitrooxylation zinc catalyst; keto nitrooxy amide preparation enantioselective; benziodoxole cyclic keto amide nitrooxylation zinc catalyst.
The first asym. nitrooxylation of cyclic β-keto esters/amides I [R = H, 4-OMe, 5-Cl, 6-Me, etc.; R1 = tert-butoxy, methoxy, (adamantan-1-yl)amino, dibenzylamino, etc.] with an easily accessible hypervalent iodine-based nitrooxylating reagent is reported. The reaction was catalyzed using the combination of Zn(ClO4)2.6H2O and a dbfox ligand under mild reaction conditions and could also be scaled up to gram quantities, providing a series of α-nitrooxy β-keto esters/amides II in high yields (84%-99%) and with low to moderate enantioselectivities (up to 78% ee).
Organic Chemistry Frontiers published new progress about Amides, oxo Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics