Lam, Hon Wai; Joensuu, Pekka M. published the artcile< Cu(I)-Catalyzed reductive aldol cyclizations: Diastereo- and enantioselective synthesis of β-hydroxy lactones>, SDS of cas: 112-63-0, the main research area is stereoselective cyclization hydroxycarboxylic acid hydroxy ketone ester; copper catalyst aldol cyclization hydroxy lactone.
Copper bisphosphine complexes catalyze the intramol. reductive aldol reaction of α,β-unsaturated esters with ketones, affording five- and six-membered β-hydroxy lactones in high stereoselectivities. Thus, reaction of trans-MeCOCH2CH2O2CCH:CHPh in THF containing Cu(OAc)2, 1,1′-bis(diphenylphosphino)ferrocene, and tetramethyldisilazane gave the hydroxypyranone I in 72% yield. Utilization of chiral nonracemic bisphosphines rendered the cyclizations enantioselective.
Organic Letters published new progress about Aldol condensation catalysts (intramol.). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics