Lagemann, Annika; Dunkel, Andreas; Hofmann, Thomas published the artcile< Activity-Guided Discovery of (S)-Malic Acid 1'-O-β-Gentiobioside as an Angiotensin I-Converting Enzyme Inhibitor in Lettuce (Lactuca sativa)>, Formula: C6H10O5, the main research area is Lactuca malic acid gentiobioside natural antihypertensive ACE inhibitor.
Angiotensin-converting enzyme (ACE), playing a crucial role in the renin angiotensin aldosterone system, is well-known to catalyze the conversion of the decapeptide angiotensin I into the physiol. active octapeptide angiotensin II, triggering blood pressure increasing mechanisms. To meet the demand for natural phytochems. as antihypertensive agents in functional food development, extracts prepared from a series of vegetables were screened for their ACE-inhibitory activity by means of a LC-MS/MS-based in vitro assay. By far the highest ACE inhibition was found for a lettuce extract, in which the most active compound was located by means of activity-guided fractionation. LC-MS, NMR spectroscopy, and hydrolysis experiments followed by ion chromatog. led to the unequivocal identification of the ACE inhibitor as the previously not reported (S)-malic acid 1′-O-β-gentiobioside. This glycoside represents a novel class of ACE-inhibiting phytochems. with a low IC50 value of 27.8 μM. First incubation experiments in saliva and aqueous hydrochloric acid demonstrated the stability of (S)-malic acid 1′-O-β-gentiobioside against salivary glycosidases and stomach acid.
Journal of Agricultural and Food Chemistry published new progress about Angiotensin-converting enzyme inhibitors. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Formula: C6H10O5.
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