Kaur, Ravneet; Singh, Dipak; Singh, Ravi P. published their research in Journal of Organic Chemistry in 2021. The article was titled 《Stereoselective Synthesis of Dihydrocoumarins via [1,2]-Phospha-Brook Rearrangement in Three-Component Coupling Reaction of α-Ketoesters, o-Quinone Methides, and Dialkyl Phosphites》.Product Details of 4755-77-5 The article contains the following contents:
A highly regio- and diastereoselective approach for the synthesis of phosphate substituted dihydrocoumarins I (R1 = 4-methoxyphenyl, 2-(4-methylphenyl)ethenyl, 2-phenylethenyl, etc.; R2 = Ph, 3-bromophenyl, 2-thienyl, etc.; R3 = i-Pr, Et, Ph) via Bronsted base catalyzed [1,2]-phospha-Brook rearrangement is reported. The two-step, one-pot Michael addition of α-phosphonyloxy enolates proceeds by coupling of dialkyl phosphite HP(=O)(OR3)2 and α-ketoesters R2C(O)C(O)OEt to o-quinone methides II, followed by an intramol. cyclization, providing 3,4-dihydrocoumarin frameworks I. The results came from multiple reactions, including the reaction of Ethyl oxalyl monochloride(cas: 4755-77-5Product Details of 4755-77-5)
Ethyl oxalyl monochloride(cas: 4755-77-5) belongs to acyl chlorides. In the laboratory, acyl chlorides are generally prepared by treating carboxylic acids with thionyl chloride (SOCl2). The reaction is catalyzed by dimethylformamide and other additives.Product Details of 4755-77-5
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