Kaieda, Akira; Yanada, Reiko; Takemoto, Yoshiji published the artcile< Indium(0)-mediated diastereoselective allylation reaction and its application to synthesis of manzacidin A>, Category: esters-buliding-blocks, the main research area is indium mediated diastereoselective allylation reaction; manzacidin A intermediate synthesis.
Indium is comparatively stable in air. The first ionization potential of indium (5.8 eV) is as low as that of Na (5.1 eV). For these reasons, indium is one of the most notable metals at present. Two alkylation methods (Barbier-type alkylation and palladium mediated alkylation) of optically active imino alc.-type aldimine with indium were developed. The reaction proceeded regio- and diastereoselectively to give optically active homoallylamine derivatives in high yields. Manzacidins are bromopyrrole alkaloids and are found to be pharmacol. useful as α-adrenoceptor blockers, antagonists of serotonergic receptor, and actomyosin ATPase activators. The authors planned the synthesis of manzacidin A via the following key step : stereoselective methallylation of an oxazolidine derivative with indium to give a methallylated compound which was then converted in 2 steps to an intermediate for the synthesis of manzacidin A. Further synthetic studies of manzacidin A are now in progress.
Tennen Yuki Kagobutsu Toronkai Koen Yoshishu published new progress about Allylation, stereoselective. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.
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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics