In 2022,Godfrey, Robert C.; Jones, Helen E.; Green, Nicholas J.; Lawrence, Andrew L. published an article in Chemical Science. The title of the article was 《Unified total synthesis of the brevianamide alkaloids enabled by chemical investigations into their biosynthesis》.Name: H-Trp-OMe.HCl The author mentioned the following in the article:
The bicyclo[2.2.2]diazaoctane alkaloids are a vast group of natural products which have been the focus of attention from the scientific community for several decades. This interest stems from their broad range of biol. activities, their diverse biosynthetic origins, and their topol. complex structures, which combined make them enticing targets for chem. synthesis. In this article, full details of authors synthetic studies into the chem. feasibility of a proposed network of biosynthetic pathways towards the brevianamide family of bicyclo[2.2.2]diazaoctane alkaloids are disclosed. Insights into issues of reactivity and selectivity in the biosynthesis of these structures have aided the development of a unified biomimetic synthetic strategy, which has resulted in the total synthesis of all known bicyclo[2.2.2]diazaoctane brevianamides and the anticipation of an as-yet-undiscovered congener. In the experiment, the researchers used many compounds, for example, H-Trp-OMe.HCl(cas: 7524-52-9Name: H-Trp-OMe.HCl)
H-Trp-OMe.HCl(cas:7524-52-9) is one of amino acid derivatives. Amino acid derivatives represent an important category of skin penetration promoters. These compounds possess hydrophobic chains attached to an amino acid headgroup via a biodegradable ester bond. Due to the amphiphilic nature of these derivatives, it is possible for them to enter into the SC lipid barrier and significantly disorganize skin membrane lipids.Name: H-Trp-OMe.HCl
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics