Garnier, Louis; Vidal, Chrystelle; Chinot, Olivier; Cohen-Jonathan Moyal, Elisabeth; Djelad, Apolline; Bronnimann, Charlotte; Bekaert, Lien; Taillandier, Luc; Frenel, Jean-Sébastien; Langlois, Olivier; Colin, Philippe; Menei, Philippe; Dhermain, Frédéric; Carpentier, Catherine; Gerazime, Aurélie; Curtit, Elsa; Figarella-Branger, Dominique; Dehais, Caroline; Ducray, François published the artcile< Characteristics of Anaplastic Oligodendrogliomas Short-Term Survivors: A POLA Network Study.>, Category: esters-buliding-blocks, the main research area is Karnofsky Performance Status; age; anaplastic oligodendroglioma; chemotherapy; proliferation; radiotherapy; seizure; surgery.
BACKGROUND: Anaplastic oligodendrogliomas IDH-mutant and 1p/19q codeleted (AO) occasionally have a poor outcome. Herein we aimed at analyzing their characteristics. METHODS: We retrospectively analyzed the characteristics of 44 AO patients with a cancer-specific survival <5 years (short-term survivors, STS) and compared them with those of 146 AO patients with a survival ≥5 years (classical survivors, CS) included in the POLA network. RESULTS: Compared to CS, STS were older (P = .0001), less frequently presented with isolated seizures (P < .0001), more frequently presented with cognitive dysfunction (P < .0001), had larger tumors (P = .= .003), a higher proliferative index (P = .= .0003), and a higher number of chromosomal arm abnormalities (P = .= .02). Regarding treatment, STS less frequently underwent a surgical resection than CS (P = .= .0001) and were more frequently treated with chemotherapy alone (P = .= .009) or with radiotherapy plus temozolomide (P = .= .05). Characteristics independently associated with STS in multivariate analysis were cognitive dysfunction, a number of mitosis > 8, and the absence of tumor resection. Based on cognitive dysfunction, type of surgery, and number of mitosis, patients could be classified into groups of standard (18%) and high (62%) risk of <5 year survival. CONCLUSION: The present study suggests that although STS poor outcome appears to largely result from a more advanced disease at diagnosis, surgical resection may be particularly important in this population. The oncologist published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.
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