In 2017,Duan, Sujuan; Guo, Lu; Shi, Dandan; Shang, Mengmeng; Meng, Dong; Li, Jie published 《Development of a novel folate-modified nanobubbles with improved targeting ability to tumor cells》.Ultrasonics Sonochemistry published the findings.HPLC of Formula: 51644-96-3 The information in the text is summarized as follows:
Conjugation of folate (FOL) to nanobubbles could enhance the selective targeting to tumors expressing high levels of folate receptor (FR). To further improve the selective targeting ability of FOL-modified nanobubbles, a novel FOL-targeted nanobubble ((FOL)2-NB) with increasing FOL content (accomplished by linking two FOL mols. per DSPE-PEG2000 chain) was synthesized, through the methods of mech. shaking and low-speed centrifugation based on lipid-stabilized perfluoropropane. The bubble size and distribution range were measured by dynamic light scattering (DLS). Enhanced imaging ability was evaluated using a custom-made agarose mold with a clin. US imaging system at mech. indexes of up to 0.12 at a center frequency of 9.0 MHz. Targeted ability was also carried out in human breast cancer MCF-7 cells, which over-express the FR, by fluorescence activated cell sorting (FACS) and fluorescence microscopy, resp. (FOL)2-NB with a particle size of 286.87 ± 22.96 nm were successfully prepared, and they exhibited superior contrast imaging effect. FACS and fluorescence microscopy studies showed greater cellular targeting ability in the group of (FOL)2-NB than in their control group of Non-targeted-NB (no FOL targeted nanobubbles) and FOL-NB (one FOL mol. per DSPE-PEG2000 chain). These results suggest that a new type of stronger targeted nanobubble was successfully prepared by increasing the FOL content per DSPE-PEG2000 chain. This novel (FOL)2-NBs are potentially useful for ultrasound mol. imaging and treatment of FR-pos. tumors and are worthy for further investigation. The experimental part of the paper was very detailed, including the reaction process of tert-Butyl (5-aminopentyl)carbamate(cas: 51644-96-3HPLC of Formula: 51644-96-3)
Some of the reported applications of tert-Butyl (5-aminopentyl)carbamate(cas: 51644-96-3) include: synthesis of of a supermacrocycle that self-assemble to form organic nanotubes., preparation of water-soluble unsymmetrical sulforhodamine fluorophores from monobrominated sulfoxanthene dye, synthesis of functionalized porphyrins as biocompatible carrier system for photodynamic therapy (PDT).HPLC of Formula: 51644-96-3
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics