Bollag, Wendy B.; Helwa, Inas; Choudhary, Vivek; Chen, Xunsheng; Kaddour-Djebbar, Ismail published the artcile< Response to letter to the editor on ""anti-psoriatic drug monomethylfumarate increases nuclear factor erythroid 2-related factor 2 levels and induces aquaporin-3 mRNA and protein expression"">, Application of C19H34O2, the main research area is polemic antipsoriatic drug monomethylfumarate Nrf2 aquaporin 3.
A polemic in response to Lai and colleagues (anti-psoriatic drug monomethylfumarate increases nuclear factor erythroid 2-related factor 2 levels and induces aquaporin-3 mRNA and protein expression). The author agree that mechanism by which monomethylfumarate acts is unclear, which led to investigate its effects on nuclear factor erythroid 2-related factor 2 levels. The author disagree that oxidative stress simply promotes psoriasis lesions to be insufficient data to determine whether oxidative stress is etiol. factor for this disease. Nrf2 play role in keratinocytes and skin is likely complex and dependent on levels of Nrf2 relative to other members of Nrf family and addnl. components of pathway, extent of exposure to oxidative stress, and induces aquaporin-3 mRNA and protein expression in human and mouse keratinocytes. The author concludes that involvement of Nrf2 in keratinocyte proliferation and differentiation is conflicting, with results supporting its participation in both processes.
Journal of Pharmacology and Experimental Therapeutics published new progress about Antipsoriatic agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics