《Synthesis and cytotoxicity of thieno[2,3-b]pyridine derivatives toward sensitive and multidrug-resistant leukemia cells》 was published in Acta Chimica Slovenica in 2021. These research results belong to Al-Trawneh, Salah A.; Tarawneh, Amer H.; Gadetskaya, Anastassiya V.; Seo, Ean-Jeong; Al-Ta’ani, Mohammad R.; Al-Taweel, Samir A.; El-Abadelah, Mustafa M.. Formula: C7H13NO2 The article mentions the following:
A new series of substituted Et 7-cyclopropyl-2-(2-aryloxo)-3-nitro-4-oxo-4,7-dihydrothieno[2,3-b]pyridine-5-carboxylates I (R = H, CHO; X = H, 4-Me, 4-Cl; Y = O, S) were prepared by utilizing Et 2-chloro-7-cyclopropyl-3-nitro-4-oxo-4,7-dihydrothieno[2,3-b]pyridine-5-carboxylate (1) and replacing of the 2-chlorine with anions obtained from phenol, salicylaldehyde derivatives like salicylaldehyde, 5-methylsalicylaldehyde and 5-chlorosalicylaldehyde or thiophenol, leading to the resp. Et 7-cyclopropyl-2-(2-aryloxo)-3-nitro-4-oxo-4,7-dihydrothieno[2,3-b]pyridine-5-carboxylates I. The new compounds I were evaluated for their in vitro cytotoxicity towards sensitive CCRF-CEM and multidrug-resistant CEM/ADR5000 leukemia cells. The screening revealed that compounds I (R = X = H, Y = O; R = CHO, X = H, Y = O; R = X = H, Y = S) inhibited the growth of both cell lines. Compound I (R = CHO, X = H, Y = O), with a phenol moiety, exhibited the highest growth inhibitory activity against CEM/ADR5000 and CCRF-CEM cells with IC50 values 4.486 ± 0.286 and 2.580 ± 0.550μM, resp. Collectively, the presented results demonstrate that the synthesized thieno[2,3-b]pyridines I warrant further exploration for potential use as anti-cancer agents. After reading the article, we found that the author used Ethyl 3-(dimethylamino)acrylate(cas: 924-99-2Formula: C7H13NO2)
Ethyl 3-(dimethylamino)acrylate(cas: 924-99-2) belongs to anime. Left-handed and right-handed forms (mirror-image configurations, known as optical isomers or enantiomers) are possible when all the substituents on the central nitrogen atom are different (i.e., the nitrogen is chiral). With amines, there is extremely rapid inversion in which the two configurations are interconverted.Formula: C7H13NO2
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Ester – an overview | ScienceDirect Topics