Acemoglu, Murat; Allmendinger, Thomas; Calienni, John; Cercus, Jacques; Loiseleur, Olivier; Sedelmeier, Gottfried H.; Xu, David published the artcile< Synthesis of new N-aryl oxindoles as intermediates for pharmacologically active compounds>, Category: esters-buliding-blocks, the main research area is phenylacetic acid arylamino preparation; oxindole aryl preparation ring opening.
Various new N-aryl oxindoles I (R1 = Me, Et; R2 = 2-Cl-6-FC6H3, 2,3,6-F3C6H2, 2,6-Cl2-4-MeC6H2, etc.) were synthesized as intermediates for the preparation of pharmacol. active 2-(N-arylamino)phenylacetic acids II. Two novel approaches were explored for the construction of diarylamine and N-aryl oxindole core structures, in addition to Buchwald arylamination and Smiles rearrangement. Condensation of anilines with 2-oxo-cyclohexylidene-acetic acid derivatives and subsequent dehydrogenation is a new and viable method for the preparation of N-aryl oxindoles.
Tetrahedron published new progress about Aromatic amines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics