Zheng, Xiao; Huang, Pei Qiang; Ruan, Yuan Ping; Lee, Albert W. M.; Chan, Wing Hong published the artcile< A new asymmetric synthesis of (R)-3-methylpyrrolidine alkaloids starting from (S)-malic acid>, Formula: C6H10O5, the main research area is methylpyrrolidine alkaloid asym synthesis malate; pyrrolidine methyl alkaloid asym synthesis; leptothoracine synthesis.
Diastereoselective methylation of di-Me (S)-malate followed by two three-step reductive dehydroxylation procedures afforded di-Me (R)-2-methylsuccinate in 80.2% and 84.7% ee resp., the later was further transformed into the natural enantiomers of ant venom alkaloids (R)-leptothoracine (I) and (R)-3-methyl-N-(2-phenylethyl)pyrrolidine and (3R,2’S)-3-methyl-N-(2-methylbutyl)pyrrolidine.
Heterocycles published new progress about Alkaloids Role: SPN (Synthetic Preparation), PREP (Preparation) (pyrrolidine). 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Formula: C6H10O5.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics