In 2022,Serusi, Lorenzo; Palombi, Laura; Pierri, Giovanni; Mola, Antonia Di; Massa, Antonio published an article in Journal of Organic Chemistry. The title of the article was 《Asymmetric Cascade Aza-Henry/Lactamization Reaction in the Highly Enantioselective Organocatalytic Synthesis of 3-(Nitromethyl)isoindolin-1-ones from α-Amido Sulfones》.SDS of cas: 4248-19-5 The author mentioned the following in the article:
The asym. synthesis of novel 3-substituted isoindolinones, e.g., I was herein reported. A new cascade reaction was developed that consisted of the asym. nitro-Mannich reaction of suitable α-amido sulfones designed from 2-formyl benzoates, followed by the in situ cyclization of the adducts. Very high enantioselectivities, up to 98% ee, and very good yields were obtained in the presence of the readily available neutral bifunctional organocatalyst derived from trans-1,2-diaminocyclohexane, which was known as Takemoto’s catalyst. The investigation of the reactivity of the obtained products allowed either the selective Boc-deprotection or reduction of the nitro group, leading to further functionalized 3-substituted isoindolinones without affecting the enantiomeric purity. The results came from multiple reactions, including the reaction of tert-Butyl carbamate(cas: 4248-19-5SDS of cas: 4248-19-5)
tert-Butyl carbamate(cas: 4248-19-5) belongs to anime. Amines characteristically form salts with acids; a hydrogen ion, H+, adds to the nitrogen. With the strong mineral acids (e.g., H2SO4, HNO3, and HCl), the reaction is vigorous. Salt formation is instantly reversed by strong bases such as NaOH. Neutral electrophiles (compounds attracted to regions of negative charge) also react with amines; alkyl halides (R′X) and analogous alkylating agents are important examples of electrophilic reagents.SDS of cas: 4248-19-5
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