Rawale, Dattatraya Gautam; Thakur, Kalyani; Sreekumar, Pranav; T. K., Sajeev; A., Ramesh; Adusumalli, Srinivasa Rao; Mishra, Ram Kumar; Rai, Vishal published an article in 2021. The article was titled 《Linchpins empower promiscuous electrophiles to enable site-selective modification of histidine and aspartic acid in proteins》, and you may find the article in Chemical Science.Name: N-tert-Butoxycarbonylhydroxylamine The information in the text is summarized as follows:
The conservation of chemoselectivity becomes invalid for multiple electrophilic warheads during protein bioconjugation. Consequently, it leads to unpredictable heterogeneous labeling of proteins. Here, we report that a linchpin can create a unique chem. space to enable site-selectivity for histidine and aspartic acid modifications overcoming the pre-requisite of chemoselectivity. The experimental process involved the reaction of N-tert-Butoxycarbonylhydroxylamine(cas: 36016-38-3Name: N-tert-Butoxycarbonylhydroxylamine)
N-tert-Butoxycarbonylhydroxylamine(cas: 36016-38-3) belongs to anime. The reaction of alkyl halides, R―X, where X is a halogen, or analogous reagents with ammonia (or amines) is useful with certain compounds. Not all alkyl halides are effective reagents; the reaction is sluggish with secondary alkyl groups and fails with tertiary ones. Its usefulness is largely confined to primary alkyl halides (those having two hydrogen atoms on the reacting site).Name: N-tert-Butoxycarbonylhydroxylamine
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics