《Copper-catalyzed enantioselective direct α-C-H amination of β-dicarbonyl derivatives with aryl hydroxylamines and mechanistic insights》 was published in Molecular Catalysis in 2020. These research results belong to Rajmani Singh, Rahul Kumar; Karsili, Tolga N. V.; Srivastava, Radhey. Product Details of 609-14-3 The article mentions the following:
Authors report a novel and efficient Cu-catalyzed direct asym. amination of tertiary β-carbonyl compounds using aryl hydroxylamine as electrophilic nitrogen donor. The process facilitates the convenient and direct synthesis of chiral α-amino carbonyl derivatives, without the need for any post-reaction manipulation. This method reveals an effective strategy for the synthesis of enantioenriched α-C-H aminated derivatives which is hitherto challenging. The choice of the robust chiral indabox ligand was ascertained to be very crucial for the desired enantioselectivity in the contemporary transformation. The reaction mechanism is fully supported by ab initio electronic structure calculations The reaction is facile, efficient and performs well at room temperature with an enantiomeric excess (ee) up to 93%. The experimental part of the paper was very detailed, including the reaction process of Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3Product Details of 609-14-3)
Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3) belongs to ketone compounds. Ketones are highly reactive, although less so than aldehydes, to which they are closely related. Much of their chemical activity results from the nature of the carbonyl group. Ketones readily undergo a wide variety of chemical reactions.Product Details of 609-14-3
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