《Encoding BRAF inhibitor functions in protein degraders》 was written by Miller, Daniel S. J.; Voell, Sabine A.; Sosic, Izidor; Proj, Matic; Rossanese, Olivia W.; Schnakenburg, Gregor; Gutschow, Michael; Collins, Ian; Steinebach, Christian. Quality Control of tert-Butyl carbamateThis research focused onVemurafenib derivative BRAF kinase inhibitor antitumor activity. The article conveys some information:
Various BRAF kinase inhibitors were developed to treat cancers carrying the BRAFV600E mutation. First-generation BRAF inhibitors could lead to paradoxical activation of the MAPK pathway, limiting their clin. usefulness. Here, we show the development of two series of BRAFV600E-targeting PROTACs and demonstrate that the exchange of the inhibitor scaffold from vemurafenib to paradox-breaker ligands resulted in BRAFV600E degraders that did not cause paradoxical ERK activation. In the experimental materials used by the author, we found tert-Butyl carbamate(cas: 4248-19-5Quality Control of tert-Butyl carbamate)
tert-Butyl carbamate(cas: 4248-19-5) belongs to anime. Hydrogen peroxide (H2O2) and peroxy acids generally add an oxygen atom to the nitrogen of amines. With primary amines, this step is normally followed by further oxidation, leading to nitroso compounds, RNO, or nitro compounds, RNO2. Secondary amines are converted to hydroxylamines, R2NOH, and tertiary amines to amine oxides, R3NO.Quality Control of tert-Butyl carbamate
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