Majewski, Arkadiusz; Przychodzen, Witold published their research in Synthetic Communications in 2021. The article was titled 《Atom-economic thiophosphoroselenenylations of C-H acid esters and amides》.Computed Properties of C7H12O3 The article contains the following contents:
Three improved thiophosphoroselenenylation procedures of CH-acids, including derivatives of malonic and acetyl-, phosphono-, 4-nitrophenyl- and 3-pyridylacetic acids, have been described and compared to previously reported thiophosphoroselenylation of di-Et malonate using bis(disopropoxyphosphinothioyl)diselenide alone or with the aid of Me iodide. The use of iodine makes it possible to utilize both equivalent of the selenenylating agent. The procedures work well for the majority of nucleophiles in a pKa range between more acidic malononitrile or Meldrum acid and less acidic phenylacetates. The reaction carried out on di-Et malonate in boiling rectified ethanol yields selenoacetate, which cannot be obtained by direct phosphoroselenenylation. Crystal structure of one of the selenomalonamides confirms the stabilization effects of both carbonyl oxygens on selenium atom. The P-Se bond splitting, using TBAF in 3-M excess in the presence of alkylating agent yields the resp. C,Se-dialkyl derivatives In the experiment, the researchers used Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3Computed Properties of C7H12O3)
Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3) belongs to ketone compounds. Ketones are highly reactive, although less so than aldehydes, to which they are closely related. Much of their chemical activity results from the nature of the carbonyl group. Ketones readily undergo a wide variety of chemical reactions.Computed Properties of C7H12O3
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics