Lu, Can; Chen, Xi; Yan, Yuanliang; Ren, Xinxin; Wang, Xiang; Peng, Bi; Cai, Yuan; Liang, Qiuju; Xu, Zhijie; Peng, Jinwu published the artcile< Aberrant expression of ADARB1 facilitates temozolomide chemoresistance and immune infiltration in glioblastoma>, Computed Properties of 112-63-0, the main research area is glioblastoma immune infiltration ADARB1 temozolomide chemoresistance tumorigenesis prognosis bioinformatics; ADARB1; akt; glioblastoma; immune; temozolomide.
Chemoresistance, especially temozolomide (TMZ) resistance, is a major clin. challenge in the treatment of glioblastoma (GBM). Exploring the mechanisms of TMZ resistance could help us identify effective therapies. Adenosine deaminases acting on RNA (ADARs) are very important in RNA modification through regulating the A-to-I RNA editing. Recent studies have shown that ADARs regulate multiple neurotransmitter receptors, which have been linked with the occurrence and progress of GBM. Here, data from several bioinformatics databases demonstrated that adenosine deaminase RNA specific B1 (ADARB1), also named ADAR2, was upregulated in both GBM tissues and cells, and had the prognostic value in GBM patients. Moreover, ADARB1 was found to be involved in AKT-mediated TMZ resistance in GBM cells. The KEGG anal. of ADARB1-associated co-expressed genes showed that ADARB1 was potentially involved in the mitochondrial respiratory chain complex. TISIDB and GEPIA databases were further used to analyze the role of ADARB1 in tumor-immune system interactions in GBM. These findings deepened our understanding of the function of ADARB1 in tumorigenesis and therapeutic response in GBM. aberrant expression of ADARB1 facilitates temozolomide chemoresistance and immune infiltration in human with glioblastoma
Frontiers in Pharmacology published new progress about Animal gene Role: BSU (Biological Study, Unclassified), BIOL (Biological Study) (TAP2). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics